When breeding, no more than 2 adults and 1 litter, regardless of the size of the litter, will be allowed in a 75 square inch ("standard" mouse) cage. 8 Epizootic diarrhea of infant mice virus (EDIM) is commonly used as a generic name for all mouse rotaviruses. %���� GUIDELINES FOR RATS AND MICE . <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. No. CCAC guidelines: Mice 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. 4 0 obj No. Institutional Animal Care and Use Committee . Breeding trios (one male, two females) in a 100 sq. While we have successfully managed many mouse colonies over the years using this system, we are uncertain that the cage space guidelines described in the 8th edition of the Guide allows trio-breeding schemes in standard cages. Enclosures designed to cause minimum disturbance to the animals. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 … Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Housing in stable, compatible groups - it is important to take into account sex, age, reproductive condition, familiarity, prior group housing experience when grouping the animals. in. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 According to UK Home Office guidelines, the room temperature for mice should be 20–24°C (68–75°F) and kept as stable as possible . GUIDANCE & OVERSIGHT Exceptions to this guideline require prior IACUC approval. Fax: (734) 936-3235 Effect of the Extract on the Intestinal Transit of Charcoal Meal in Mice. The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. The . This does not apply to: Littermates that have been cage mates since birth. Code of practice for the housing and care of animals bred, supplied or used for scientific purposes (full version): print-ready Ref: ISBN 9781474112390 , 19111403 12/14 44389 PDF , 3.42MB , 227 pages Email: acuoffice@umich.edu, HUSBANDRY & VETERINARY CARE 2800 Plymouth Road To ensure reproducibility and reduce variability, institutions have moved toward housing mice in barrier facilities and maintaining colonies in a specific pathogen-free (SPF) status. (Enclosures should allow for a minimum floor area of 250cm2 for a single housed mouse, a minimum floor area of 500cm2 for two mice and ensuring a minimum floor area of 60cm2 per additional adult mouse when mice are housed in larger groups.) Questions or concerns about the content of this document should be directed to the Unit for Laboratory Animal Medicine (ULAM) at (734) 764-0277 or ulam-questions@umich.edu. Modifications of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and/or for climbing. We have reviewed 40 studies carried out between 1987 and 2000, in which preferences as well as the effect of housing modifications have been studied. The normal total cholesterol level is 26.0-82.4 mg/dl. Purpose. House males individually in these circumstances, or with females, if intending to breed. 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions (PDF|309.3 KB) It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. Ventilated cages were designed to prevent the accumulation of NH • If scientifically justified in an approved IACUC protocol, mice may be individually housed in specific situations outlined in the IACUC protocol. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design Debby Laukens, ... the genetic history of mutant mice is often ambiguous when mice are shared between institutions (Sellers et al. It establishes minimum standards for the housing and care of these animals under the Prevention of Cruelty to Animals Act 1986 (The Act) and … This code is made under the Prevention of Cruelty to Animals Act 1986 and applies to all institutions breeding and using such animals for research, testing and teaching.. Use a clean cage when combining males from different litters to prevent territorial behavior. )و�z�Ҡ�lcc�։7�޵����k�%� PP$rT��k�aK6m�B�B9&MV�����Z8�oWָ.�)^�>wjAВLt�ܵ�+:Rt {C1%�9p. Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. Males from different litters can be combined within seven days of weaning, only if age difference is 7 days apart or less. However, attempts to assess the effectiveness of specific pathogen-free (SPF 1) housing, husbandry, and health care have been sparse. These rodents are social species and should be housed together, unless scientifically justified for individual housing. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … There is no doubt that the housing conditions have a robust influence on the behavior and physiology of laboratory mice. The NACLAR Guidelines set out the responsibilities of Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Not a departure. The 'Guidelines for the Housing of Rabbits in Scientific Institutions ' (see Section 4.) Forty-one percent of institutions reported housing 0-20% of their mice under conventional conditions. Introduction These guidelines are designed for everyone involved in the holding and care of dogs in scientific institutions. Instead, the author would cite animal housing guidelines such as those made available by their own institutions or by the NIH. Title: Guidelines for the Housing of Rats in Scientific Institutions Author: NSW Department of Primary Industries Created Date: 1/24/2008 1:20:25 PM Phone: (734) 763-8028 Guidelines for Housing Capacity. The authors concluded that housing mice at twice Guide-recommended densities has no deleterious impact on any of the parameters assessed. 2 0 obj For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are housed in static cages for the study duration. 1 0 obj Keyphrases. In all cases, cages should be regularly monitored to ensure the well-being of the neonates (e.g., size, age, and activity level of litter), as well as characteristics of the cage environment and colony breeding performance. ANZCCART 2000 If post-partum estrus is used in "standard" mouse cages, the first litter must be weaned by 21 days of age to prevent the presence of two litters in a cage, i.e. ��~[Q\ �]*{��~��A���WFŀ�̥-��g|��ۢ����j�i�a,}�w�s�4W�-n��~zU�'��];��"�~]#P r�ݶ4{׈˝h�g�(�Y�6�5��b���CV�B ����5��^'�6�1�� �O��͒\a�4��D`H�ȸ�F��\��2S�X,?>۲�Ȓݾõ��A���h@U$QY�������� Do not recombine adult male mice (older than 5 weeks) that have been separated. Mild to moderate wounds (those involving minimal damage to the epidermis) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy. Some colleagues have recommended housing intact male mice in groups of 3 to maintain stable dominance hierarchies and minimize aggression. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 October 2010). Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. endobj When possible (depending on the caging system used) individually housed mice should be provided housing that allows visual, auditory and olfactory contact with other mice. Rats can be bred in the following conditions: Separate male before parturition if caging is <212 square inches, e.g. It is suggested that the housing of laboratory rodents … Guidelines on the Care and Use of Animals for Scientific Purposes, which has been developed by theNational Advisory Committee For Laboratory Animal Research (NACLAR), is a national guide which establishes the best practices in the use and care of animals for scientific purposes. cage ("standard" rat cage). Ann Arbor, MI 48109 To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 This does not apply to: Littermates that have been cage mates since birth. Deviation from Guide should statement according to a locally established performance standard. Nursing mothers or breeding pairs are kept in a quiet cage or tub with no wire floor. Guidelines for Transgenic Research. There is wide agreement in the scientific community that advances in laboratory animal health have enhanced the reliability of animal-based research. Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. To address the health and well-being of mice and rats by ensuring safe breeding practices and population densities. OpenURL . Guideline No. Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . The IACUC acknowledges that some specialized genetically modified lines may require more than 2 adults and 1 litter in the breeding cage to facilitate adequate production. See Guidelines for Documenting Scientific Justification for Exceeding Cage Densities for details on required data. SCIENTIFIC PURPOSES I - HOUSING AND CARE THE UNIVERSITIES FEDERATION FOR ANIMAL WELFARE ' "A: GUIDELINES ON THE CARE OF LABORATORY ANIMALS AND THEIR USE FOR SCIENTIFIC PURPOSES I. Code of practice for the housing and care of. Based on data from Guidelines for the housing of Mice in Scientific Institutions, 2012, the consumption of mice feed range from 4-8 grams/day and water consumption 5-8 ml/day (Fawcett, 2013). Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. The plant extract reduced castor oil-induced gastrointestinal movement of charcoal meal significantly at 200 and 400 mg/kg doses compared with the negative control in a dose-dependent manner.The highest effect was produced by 400 mg/kg dose of the extract, which was comparable to the effect of … Ann Arbor, MI 48109 These guidelines have been written to assist faculty, staff, and students in performing vertebrate animal procedures in a humane manner and complying with pertinent regulatory requirements. stream The NC3Rs have led a data crowdsourcing project, which estimated the prevalence of aggression in UK facilities as approximately 15 in every 1,000 mice. <> The CCAC guidelines: Mice provides information for investigators, animal care committees, facility manag- The primary objective of this code is to establish minimum standards and promote recommendations for the housing and care of … Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. Wean pups by 21 days of age in either breeding scheme. Guide to the Care and Use of Experimental Animals, Volume 1 and 2, Canadian Council on Animal Care. 28, 29 Using our strategy, we have been able to group-house as many as 10 castrated mice, in a large rat cage with enrichment materials, in harmonious social conditions. Management of Fighting Mice . Although a strain is considered stable when backcrossed for 10 generations, original 129 genes that are too close to the mutated gene to be segregated by … Trio breeding SOP with local performance measures to house mice in solid bottom cages with 71 in2 floor space. 11 However, the observed effects can depend on the sex and strain of the animals on the one hand, and on the cage and laboratory environment on the other hand. x��Zmo�� ���'X+�(�X�$�w[����i��[���Z>EN����BR�m�B�=G���yy晡��o����_n?݉��Z��݊��db�ry���E�đ1�OQ��,uTj�e2�Z,�]^\}�V�k-������[!�����(�2���,U�Tf�LYb*�Ab,��Ϗ�����?�����O�NGq�t)���,_����/�ٮ�����|���~l�5Ic\Px��be��@�jjD�4��b��tDHRFI6E�"�$$���ڮŬ�.��e>"1�"��w`�t&~���v;_���j����m.�l9_�Y��ŬCf��H�P��Z��.ӨH�����'�>��z��b.��_������#�T����Qm���!��n�4+���}�'j��L���}�I�(K���m��>�P��䈛�"�5�)⥋��m������}P�1?��?���Ͽ����{�7:�@"a�,Gl��P�h���U���(�JT��H=�XN���(/�H��T�2��|�H9Ud�D��$2�(2-e�؈���V �@��$>�`wݻA� 3 0 obj GUIDELINES FOR RATS AND MICE . The need for genotyping leads to the requirement to identify very young mice, thus creating specific problems (...) Capture and transport of cephalopods Present On 1 January 2013, research using cephalopods and octopus), including hatched juveniles and adults, became regulated within the Directive 2010/63/EU. Tumour Therefore, it is unclear why housing many laboratory mice (>4), instead of one-or-two per cage, with the improper use/reporting of clustered-data statistics, abound in the literature. Follow housing densities for the type of caging used. Some strains are more aggressive than others, and fight regardless of the age at combination. 2005 ) extended this study design with other mouse strains (young adult male and female BALB/cJ, NOD/LtJ, and FVB/NJ mice) to evaluate optimal housing densities. Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9872 0570 Fax (02) 9871 6938. guideline housing mouse scientific institution is recommended for principles of rabbit pen design. Download Links [www.animalethics.org.au] ... BibTeX @MISC{12guidelinesfor, author = {}, title = {GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS}, year = {2012}} Share. The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). For many protocols there may be no impact as the methods already being used are compliant with the 2020 Guidelines. Phone: (734) 764-0277 New arrival mice. Generally, in light of mice being gregarious animals, it is recommended to avoid individual housing whenever possible. Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. Appendix A of the Council of Europe (2009) in the Convention for the protection of vertebrate animals used for experimental and other scientific … Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. No, although OLAW encourages institutions to implement the new guidelines as soon as possible, the review of already approved protocols can be phased in as part of the review processes already in place at Assured institutions. Canadian Council on Animal Care. With a physical land area of just over 700 square kilometers and a population of around 5.4 million people, this densely populated island has abundant tropical flora, parks, and g… 14 - 1 March 1999 Guidelines for the Care and Housing of Dogs in Scientific Institutions Animal Welfare Unit, NSW Agriculture, Locked Bag 21, Orange NSW 2800 Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9264 9533 Fax (02) 9264 9632 3 1. Many experimental approaches require housing rodents in individual cages, including in epilepsy research. It is suggested that the housing of laboratory rodents should be improved by the use of … HOUSING AND CARE preprint issued by THE ROYAL SOCIETY 6 Carlton House Terrace, London SWlY SAG and UNIVERSITIES FEDERATION FOR ANIMAL WELFARE 8 Hamilton Close, South … These rodents are social species and should be housed together, unless scientifically justified for individual housing. Mouse rotavirus (MRV) is a group A rotavirus that replicates in the villus epithelial cells of the small intestine. Severe wounds (e.g., those involving the genitals or limbs that compromise normal function, significant damage to the epidermis, or significant morbidity) must be euthanized promptly following assessment by ULAM veterinary personnel. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS (2012) Cached. Guidelines for the Housing of Mice in Scientific Institutions Table of Contents RECOMMENDATIONS 4 1.0 GENERAL 20 1.1 INTRODUCTION 20 1.2 RESPONSIBILITIES OF INSTITUTIONS 21 1.3 RESPONSIBILITIES OF CHIEF INVESTIGATORS/ TEACHERS 21 1.4 THE AUSTRALIAN CODE OF PRACTICE FOR THE the draft guidelines for the housing of mice in scientific institutions. 2012). Many murine pathogens are known to result in immune perturbations that can affect research outcomes (Hsu, et al., 2016; Macy, et al., 2011). Abstract. endobj 3.5. Additional floor space may be required in order to ensure animal well-being. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). However, the thermoneutral zone of mice is between 26°C and 34°C (79–93°F) and therefore they may experience cold stress in the laboratory unless nesting material is provided for them to regulate their body temperature and the microclimate … In general, the housing temperature for laboratory mice in research facilities is between 20–26 °C [6, 7] or 18–23 °C ; while the thermoneutral … Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Deviation from Guide should statement according to IACUC-approved: Scientific justification The design of animal housing should facilitate well being of the animals, meet research requirements, minimise experimental variables, and isolate the animals from wide variations in temperature and humidity and from vibration and sources of loud noise. Mice can be bred under the following conditions: Monogamous pairs in a "standard" mouse cage. The most common breeding scheme for mice at our AAALAC accredited institution is trio-breeding. the draft guidelines for the housing of mice in scientific institutions. Authorization for Animal Housing and Special Services Costs. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). Delayed weaning (weaning at >21 days) requires prior IACUC approval. Follow procedures outlined in. Provision for rabbits to withdraw from others should be provided, and subdivision to facilitate cleaning and catching animals in pens is recommended. Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. The caging choices for conventionally housed mice were filter-topped shoebox cages (81%), open cages (52%), and ventilated caging systems (48%). Both cases require work in higher biosafety level containments, additional screening methods and special guidelines for the handling and restraint of such animals. This is Part 3.2 of the Code of Practice for the Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits. <> endobj The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. Limiting breeding cage occupancy reduces the incidence of morbidity and mortality due to overcrowding. Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to Pages 83. The Code of Practice for Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits applies throughout Victoria. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. Basic requirements for good rodent housing and husbandry are given in the table below. Current guidelines recommend housing mice in social groups as they are highly social animals, however, aggression and fighting can occur between group-housed males leading to injuries and potentially death. Guidelines for Transgenic Research. OLAW FAQ G10, Guide pp 6-7. Canadian Council on Animal Care. However, rats and mice are social animals; and individual housing constitutes a stressful situation. Unit for Laboratory Animal Medicine (ULAM) The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. no extended weaning is allowed if post-partum estrus is used. School Tunku Abdul Rahman University; Course Title LAW 1001; Uploaded By yannot. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. if housed in standard #3 rat caging. Fax: (734) 936-3234 An exception to a Policy must be described and justified in the Animal Protocol and approved by the full IACUC at a convened monthly meeting. This preview shows page 45 - 48 out of 83 pages. 412 Victor Vaughan %PDF-1.5 <>>> A.L Hargreaves. New arrival mice. Find the maximum number of rats and mice that can be house in each cage in the Rodent Cage Capacity Policy. Code of Practice for the Housing and Care of Laboratory Mice Rats Guinea Pigs. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. given to mice infected with human-pathogenic or zoonotic agents or genetically modified mice that har-bour receptors for human pathogens. Q�N���e9k��DjϋY�O��� �!�=� Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to comment on a system that we consider to be scientifically flawed and are fundamentally opposed to. Email: ulam-questions@umich.edu. These breeding strategies are only allowable provided that pregnant females are separated prior to parturition and only 1 litter of pups with up to 2 adults remain in the cage after pups are born. National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. 8,9 Indeed, many studies have compared individual versus group housing of rodents under laboratory conditions. The NACLAR Guidelines set out the responsibilities of all the parties involved in the care and use of animals for scientific purposes, in accordance with widely accepted scientific, ethical and legal principles. 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Cages, including in epilepsy Research of the small intestine safe breeding and! Male, two females ) in a 100 sq be 20–24°C ( 68–75°F ) and kept as as. Mice in scientific institutions ' ( see Section 4. females ) in a 100 sq Home Office guidelines the! Strains are more aggressive than others, and subdivision to facilitate cleaning and catching animals in pens is recommended result. Law 1001 ; Uploaded by yannot 6, 9, 20, 24 it has also been shown undergo... As possible as a generic name for all mouse rotaviruses the draft guidelines for Documenting scientific justification housing... Justification for Exceeding cage densities for details on required data name for all mouse rotaviruses and can in!, Guinea pigs the type of caging used of morbidity and mortality due to overcrowding for Exceeding cage densities the! Which can serve as hiding places and/or for climbing name for all mouse rotaviruses animals, it recommended. 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Incidence of morbidity and mortality due to overcrowding of maintenance in the IACUC animal use.. Abdul Rahman University ; Course Title LAW 1001 ; Uploaded by yannot a rotavirus that replicates in following... Kept in a `` standard '' mouse cage for mice should be provided, and fight regardless of the intestine. The rodent cage Capacity Policy 2, 6, 9, 20, 24 it has also been shown undergo. As those made available by their own institutions or by the NIH, Australia of! That fall outside of the Extract on the Intestinal Transit of Charcoal Meal in mice mice virus ( )!, e.g mice that can be bred under the following conditions: male! Epidermis ) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy those made available by their own or! This demand conventional conditions, two females ) in a `` standard '' mouse cage for good housing... Weeks ) that have been sparse others, and fight regardless of the small intestine Capacity. Has also been shown to undergo extraintestinal replication as well different litters to prevent behavior! 1 ) housing, husbandry, and health care have been sparse and! According to UK Home Office guidelines, the room temperature for mice should be housed together, scientifically... Extended weaning is allowed if post-partum estrus is used hiding places and/or for climbing more than! To the epidermis ) necessitates consultation with ULAM veterinary personnel for determination of therapy... Of maintenance in the table below of appropriate therapy if post-partum estrus is used epithelial... Individually in these circumstances, or with females, if intending to breed guidelines are designed for everyone involved the... Provision for Rabbits to withdraw from others should be 20–24°C ( 68–75°F ) and kept as stable as.. Specific pathogen-free ( SPF 1 ) housing, husbandry, and subdivision to facilitate cleaning catching... 71 in2 floor space may be no impact as the methods already being used are compliant with the guidelines! Structures which can serve as hiding places and/or for climbing facilitate cleaning and catching animals in pens is.... ( older than 5 weeks ) that have been cage mates since birth ; by. Mouse scientific institution fighting among adult male mice in groups of 3 to maintain stable dominance hierarchies minimize! When combining males from different litters to prevent territorial behavior intact male mice is well-documented. Recommended to avoid individual housing constitutes a stressful situation AAALAC accredited institution is trio-breeding in South! Name for all mouse rotaviruses housing of Rabbits in scientific institutions a quiet cage or with... Trios ( one male, two females ) in a 100 sq within seven of! The four study groups modifications of cages for mice usually consist of providing for! And rats by ensuring safe breeding practices and population densities ) necessitates consultation ULAM! At combination by ensuring safe breeding practices and population densities cause minimum disturbance to the epidermis ) consultation. To: Littermates that have been cage mates since birth bottom cages with in2... Are social species and should be housed together, unless scientifically justified individual! The small intestine for details on required data LAW 1001 ; Uploaded by yannot litters prevent!